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        Research

        Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling

        Climate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80yrs. In this study we aimed to assess the respiratory structure and function effects of long-term exposure to 890ppm CO2 from preconception to adulthood using a mouse model. ...

        Research

        Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels

        In obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood. ...

        Research

        Genome Sequences of Two Lytic Staphylococcus aureus Bacteriophages Isolated from Wastewater

        Two lytic double-stranded DNA (dsDNA) bacteriophages, belonging to the family Herelleviridae, were isolated from wastewater in Western Australia. Biyabeda-mokiny 2 appears to belong to the genus Kayvirus, and Koomba-kaat 1 to Silviavirus. ...

        Research

        The effects of acamprosate on maternal and neonatal outcomes in a mouse model of alcohol use disorders

        Despite the teratogenic effects of alcohol, little is known about the safety of pharmacotherapies such as acamprosate for the treatment of alcohol use disorders in pregnancy. The aims of this study were to investigate, in a mouse model, the effects of maternally administered acamprosate on maternal and neonatal health, offspring neurodevelopment and behaviour, as well as examine whether acamprosate reduces the neurological harm associated with alcohol consumption in pregnancy. ...

        Research

        Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size?

        Citation: Donovan GM, Wang KCW, Elliot JG, James AL, Noble PB. Quantifying airway remodelling for research or clinical purposes: How should we ...

        Research

        Intrauterine growth restriction affects diaphragm function in adult female and male mice

        Sex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure ...

        Research

        Independent and combined effects of airway remodelling and allergy on airway responsiveness

        There was a positive relationship between the thickness of the airway smooth muscle layer with airway responsiveness, which was shifted upward in the presence of allergy ...

        Research

        The effects of electronic cigarette aerosol exposure on inflammation and lung function in mice

        This study shows, for the first time, that exposure to e-cigarette aerosol during adolescence and early adulthood is not harmless to the lungs and can result in significant impairments in lung function. ...

        Research

        Fragranced consumer products: effects on asthmatic Australians

        Most asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects ...

        Research

        Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma

        Findings provide further proof of concept that pharmacological targeting of airway smooth muscle thickness will be beneficial and may be facilitated by azithromycin ...

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