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        Research

        In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

        All alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood. ...

        Research

        The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse model

        In healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed... ...

        Research

        Emerging issues in the Pacific Basin

        This review provides a snapshot of some key environmental health issues that will provide ongoing challenges for the Pacific Basin region in the coming decades ...

        Research

        No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Authors: Foong RE, ...

        Research

        Confounding effects of gavage in mice: Impaired respiratory structure and function

        It is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality ...

        Research

        Editorial overview: The physiology of the diseased lung

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        Biodiesel feedstock determines exhaust toxicity in 20% biodiesel: 80% mineral diesel blends

        To address climate change concerns, and reduce the carbon footprint caused by fossil fuel use, it is likely that blend ratios of renewable biodiesel with commercial mineral diesel fuel will steadily increase, resulting in biodiesel use becoming more widespread. ...

        Research

        In Vitro primary human airway epithelial whole exhaust exposure

        The method outlined in this article is a customization of the whole exhaust exposure method generated by Mullins et al. (2016) using reprogrammed primary human airway epithelial cells as described by Martinovich et al. (2017). It has been used successfully to generate recently published data (Landwehr et al. 2021). The goal was to generate an exhaust exposure model where exhaust is collected from a modern engine, real-world exhaust concentrations are used and relevant tissues exposed to assess the effects of multiple biodiesel exposures. ...

        Research

        Long-term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthood

        Atmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long-term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure. ...

        Research

        Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

        A significant proportion of chronic obstructive pulmonary disease exacerbations are strongly associated with rhinovirus infection (HRV). In this study, we combined long-term cigarette smoke exposure with HRV infection in a mouse model. ...

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