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        Research

        Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

        Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

        Research

        Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity

        Our result highlighted that miRNA-target gene network contributes to human disease genetics in a cell type-specific manner ...

        Research

        Autism risk associated with parental age and with increasing difference in age between the parents

        Increases in ASD was not only limited to advancing paternal or maternal age alone but also to differences parental age including younger or older similarly age ...

        Research

        Searching for a technology-driven acute rheumatic fever test: the START study protocol

        The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. ...

        Research

        Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

        Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biase ...

        Research

        Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study

        To investigate the effect of interpregnancy interval (IPI) on preterm birth (PTB) according to whether the previous birth was preterm or term. ...

        Research

        Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells

        The generation of myeloid cells from their progenitors is regulated at the level of transcription by combinatorial control of key transcription factors... ...

        Research

        Telomerase reverse transcriptase regulates microRNAs.

        This study reports that telomerase reverse transcriptase extensively affects the expression levels of mature microRNAs. ...

        Research

        Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discovery

        This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

        Research

        The role and therapeutic implications of T cells in cancer of the lung

        This review examines the role of T cells in lung cancer, discussing the direction and clinical significance of current and future immunotherapeutic strategies ...

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