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        Research

        Parental awareness and attitudes towards prevention of respiratory syncytial virus in infants and young children in Australia

        To assess parental awareness of respiratory syncytial virus (RSV) and the level of acceptance of future RSV prevention strategies. A cross-sectional online survey was implemented targeting "future" and "current" parents of children aged ≤5 years in Australia. ...

        Research

        Determining the true incidence of seasonal respiratory syncytial virus-confirmed hospitalizations in preterm and term infants in Western Australia

        Respiratory syncytial virus contributes to significant global infant morbidity and mortality. We applied a previously developed statistical prediction model incorporating pre-pandemic RSV testing data and hospital admission data to estimate infant RSV-hospitalizations by birth month and prematurity, focused on infants aged <1 year. ...

        Research

        A Phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of V114 compared with PCV13 in healthy infants (PNEU-PED-EU-1)

        V114 (15-valent pneumococcal conjugate vaccine [PCV]) contains all serotypes in 13-valent PCV (PCV13) and additional serotypes 22F and 33F. This study evaluated safety and immunogenicity of V114 compared with PCV13 in healthy infants, and concomitant administration with DTPa-HBV-IPV/Hib and rotavirus RV1 vaccines. ...

        Research

        A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults

        No currently licensed and available vaccine has been shown to provide broad protection against endemic MnB disease. ...

        Research

        Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

        Viral respiratory infections are associated with significant morbidity and mortality. ...

        Research

        Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in children

        The aim was to document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children ...

        Research

        Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine

        Successful defence against viral pathogens requires the rapid recognition of virus-specific "danger signals" and the activation of both innate and adaptive... ...

        Research

        Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus

        Group B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility... ...

        Research

        Maternal, umbilical cord and neonatal inflammatory and hematologic markers in histologic chorioamnionitis

        Maternal, umbilical cord, neonatal inflammatory, hematologic markers, histologic chorioamnionitis... ...

        Research

        Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis

        In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live organisms ...

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