Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

This is a protocol for a Cochrane Review (intervention). The objectives were to assess the efficacy and safety of whole‐cell pertussis (wP) vaccinations in comparison to acellular pertussis (aP) vaccinations in early infancy for the prevention of atopic diseases in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

The effects of OM-85 were strongest in the first winter season, with a trend for fewer children in the OM-85 group to have sLRIs and URIs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

We aim to provide our view of where we are and where we need to go as a community of clinicians and researchers who tackle the public health problem of asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

This article looks at the clinical implications of the research into microbial exposure & protection against asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• December 2015

Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015

The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric ARI. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. Participants of the Raine Study Generation 2 cohort had 25(OH)D concentrations measured at the 6-, 14-, 17- and 20-year follow-ups. Participants underwent cycloplegic autorefraction at age 20 years, and myopia was defined as a mean spherical equivalent -0.50 dioptres or more myopic. Logistic regression was used to analyse the association between risk of myopia at age 20 years and age-specific 25(OH)D concentrations. Linear mixed-effects models were used to analyse trajectory of 25(OH)D concentrations from 6 to 20 years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021