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        Research

        Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

        We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asthma-linked. ...

        Research

        Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

        AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment. ...

        Research

        Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific

        Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear ...

        Research

        Epithelial-dendritic cell interactions in allergic disorders

        Airway epithelial cells act through multiple mechanisms to function as an important component of the pulmonary defence strategy that is crucial... ...

        Research

        Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

        To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children ...

        Research

        Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studies

        The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures ...

        Research

        Early immunological influences on asthma development: opportunities for early intervention

        Early immunological influences on asthma development: opportunities for early intervention ...

        Research

        Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

        Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways. ...

        Research

        The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges

        In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures. ...

        Research

        Vitamin D over the first decade and susceptibility to childhood allergy and asthma

        We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma. ...

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