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        Research

        Analytical bias in the measurement of plasma 25-hydroxyvitamin D concentrations in infants

        To our knowledge, this is the first study to show that the reported 25(OH)D concentration may be influenced by both age and assay type ...

        Research

        Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in Infancy

        There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards "at-risk" infants. The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. ...

        Research

        A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin

        Suggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection. ...

        Research

        T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

        To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy. ...

        Research

        The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood

        This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes. ...

        Research

        Rates and types of hospitalisations for children who have subsequent contact with the child protection system

        To determine whether children who have child maltreatment allegation or substantiation have a higher rate of general hospital admissions and injury ...

        Research

        Taking a prebiotic approach to early immunomodulation for allergy prevention

        In this review we examine maternal and infant dietary sources of prebiotics with a particular focus on non-digestible oligosaccharides, which undergo SCFA. ...

        Research

        Early introduction of food reduces food allergy – Pro and Con

        When an infant is developmentally ready, a variety of nutritious foods should be introduced including the ‘more allergenic’ foods during infancy ...

        Research

        Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth

        IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.  ...

        Research

        Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

        Maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema ...

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