Head, Immunology and Breastfeeding
MD, PhD
Professor Verhasselt is Head of Immunology and Breast Feeding at the Telethon Kids Institute. She has 20 years of experience in translational research on the impacts of breastfeeding on child immune development and health. With her team, she aims to establish the matches and, importantly, the possible mismatches, between what the infant needs for healthy development and the nutrition that they are provided. She wants to reveal what is needed to make breast milk more likely to prevent conditions such as allergy, malaria or growth failure.
She has revolutionised the field of allergy prevention by early oral allergen exposure with a landmark study published in Nature Medicine in 2008. This study contributed to the recent major changes in breastfeeding guidelines for food allergy prevention, that Prof. Verhasselt co-authored (European Academy of Allergy and Clinical Immunology food allergy prevention guidelines).
Her creative mind, expertise in immunology of breastfeeding and worldwide col-laborations have resulted in the publication of a ground-breaking study on a novel concept for Malaria prevention through natural vaccination via breast milk. Her leadership in clinical studies, aiming to improve child health through early nutrition, is shown in her current study of a birth cohort of 1000 children that investigates the importance of colostrum for growth, allergy and infection prevention. This knowledge will be informing changes in clinical practice and driving policy changes such as increased budgets in community and health services for early breastfeeding support.
Prof. Verhasselt has presented more than 40 invited lectures in the last 3 years to interna-tional scientific meetings and she has regular speaking engagements to local and internation-al meetings of stakeholders in child nutrition. She co-coordinates and lectures at the course “Breastfeeding A Foundation for Human Health” held at The University of Western Australia. Prof. Verhasselt has authored more than 80 publications, many published in top 1% Journal (Nature Medicine, JAMA Pediatrics, Gut, Lancet Infectious Disease, Journal of Allergy and Clinical Immunology).
Her research receives a major financial support by the Larsson Rosenquist Foundation.
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Publications
March 2024
Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial
Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents. The aim of this trial was to assess the effectiveness of affordable, widely available, repurposed drugs used in combination for treatment of COVID-19, which may be particularly relevant to low-resource countries.
Published research Immunisation Infectious Diseases Airway Epithelial Research Subsite: Walyan COVID-19 Immunology and Breast FeedingJanuary 2024Metagenomic Characterisation of the Gut Microbiome and Effect of Complementary Feeding on Bifidobacterium spp. in Australian Infants
Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants.
Published research Breastfeeding Early Childhood Development Nutrition Nutrition in Early Life ORIGINS Computational Biology Subsite: ORIGINS Project Clinical Epigenetics Immunology and Breast FeedingDecember 2023Study Protocol for a Stepped-Wedge Cluster (Nested) Randomized Controlled Trial of Antenatal Colostrum Expression (ACE) Instruction in First-Time Mothers: The ACE Study
Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers.
Diabetes (Type 1) Published research Breastfeeding ORIGINS Computational Biology Subsite: ORIGINS Project Immunology and Breast Feeding Maternal healthFebruary 2022Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review
Previous reports suggested that food proteins present in human milk (HM) may trigger symptoms in allergic children during breastfeeding, but existing evidence has never been reviewed systematically.
Published research Breastfeeding Nutrition in Early Life Food Allergy Allergy Immunology and Breast Feeding -
Other Publications
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Education and Qualifications
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Awards and Honours
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Active Collaborations