Team Leader, Clinical Epigenetics
BSc PhD
David is an NHMRC biomedical research fellow and Team Leader of Clinical Epigenetics at Telethon Kids Institute. His research explores the links between the molecular determinants of epigenetic control and childhood health and disease. He is engaged in understanding how periconceptual exposures translate into phenotypes with enduring effects on long-term health. He has published extensively on genetic and epigenetic mechanisms of immune development and allergic disease.
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Publications
February 2019
Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood
Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern
Asthma Published research Food Allergy Clinical EpigeneticsSeptember 2018Early life innate immune signatures of persistent food allergy
Early life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood
Published research ORIGINS Food AllergyAugust 2018Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy
Our data indicate epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex, and likely reflects pathways modified by gene-environment interactions in food allergy
Published research Food AllergyJune 2018Candidate gene testing in clinical cohort studies with multiplexed genotyping and mass spectrometry
We describe a cost-effective tag single nucleotide polymorphism approach using a multiplexed genotyping assay with mass spectrometry
Published research Clinical Epigenetics -
Education and Qualifications
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Awards/Honours
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Active Collaborations