Paediatric Infectious Diseases Clinician Researcher, Research Fellow, Raine Fellow, Deputy Director of the Wesfarmers Centre of Vaccines and Infectious Diseases
MBBS (Hons), FRACP, PhD, DTM&H, DCH
Dr Charlie McLeod is an Infectious Diseases Paediatrician, Year 1 post-doctoral researcher and recent recipient of a RAINE clinical research fellowship (2021-24) with emergent expertise in patient-centred research and novel clinical trial methodology.
Dr McLeod is a Deputy Director at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at Telethon Kids Institute, and of a member of the Centre's Infectious Diseases Implementation Research (IDIR) team. IDIR forms part of the Adaptive Health Intelligence (AHI) collaboration, which includes the Health and Clinical Analytics unit at the University of Sydney. AHI supports the design and implementation of embedded clinical trials using innovative trial methodologies and analytical approaches to create ‘learning health systems’ to simultaneously generate and translate high-quality evidence to inform practice and policy.
Dr McLeod is also an elected representative of the Scientific and Safety Committee at the Child and Adolescent Health Service HREC.
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Publications
March 2023
Core protocol for the adaptive Platform Trial In COVID-19 Vaccine priming and BOOsting (PICOBOO)
The need for coronavirus 2019 (COVID-19) vaccination in different age groups and populations is a subject of great uncertainty and an ongoing global debate. Critical knowledge gaps regarding COVID-19 vaccination include the duration of protection offered by different priming and booster vaccination regimens in different populations, including homologous or heterologous schedules.
Published research Immunisation Infectious Diseases Infectious Disease Implementation Research Infectious Diseases Epidemiology Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases COVID-19March 2023BEAT CF pulmonary exacerbations core protocol for evaluating the management of pulmonary exacerbations in people with cystic fibrosis
Cystic fibrosis (CF) is a rare, inherited, life-limiting condition predominantly affecting the lungs, for which there is no cure. The disease is characterized by recurrent pulmonary exacerbations (PEx), which are thought to drive progressive lung damage. Management of these episodes is complex and generally involves multiple interventions targeting different aspects of disease. The emergence of innovative trials and use of Bayesian statistical methods has created renewed opportunities for studying heterogeneous populations in rare diseases.
Cystic Fibrosis Published research Infectious Disease Implementation Research P4 Respiratory Health for Kids Subsite: Walyan BREATHMarch 2023among children with pneumonia using a causal Bayesian network
Pneumonia remains a leading cause of hospitalization and death among young children worldwide, and the diagnostic challenge of differentiating bacterial from non-bacterial pneumonia is the main driver of antibiotic use for treating pneumonia in children. Causal Bayesian networks (BNs) serve as powerful tools for this problem as they provide clear maps of probabilistic relationships between variables and produce results in an explainable way by incorporating both domain expert knowledge and numerical data.
Infectious Disease Implementation Research Infectious Diseases Epidemiology Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Bacterial Respiratory Infectious Disease GroupMarch 2023Patient-reported outcome measures for paediatric acute lower respiratory infection studies
Patient-reported outcome measures (PROMs) are recommended for capturing meaningful outcomes in clinical trials. The use of PROMs for children with acute lower respiratory infections (ALRIs) has not been systematically reported. We aimed to identify and characterise patient-reported outcomes and PROMs used in paediatric ALRI studies and summarise their measurement properties.
Published research Infectious Disease Implementation Research Infectious Diseases Epidemiology Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Respiratory viral infectionsSeptember 2022Protocol for establishing a core outcome set for evaluation in studies of pulmonary exacerbations in people with cystic fibrosis
Pulmonary exacerbations are associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations or how these outcomes should be measured.
Cystic Fibrosis Published research Infectious Disease Implementation Research Infectious Diseases Epidemiology Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Subsite: Walyan BREATH -
Education and Qualifications
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