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Prof Jonathan Carapetis

September 2021

Searching for a technology-driven acute rheumatic fever test: the START study protocol

The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus.

Published research Rheumatic Heart Disease Systems Immunology Group A Streptococcal & Rheumatic Heart Disease Computational Biology Systems Vaccinology
August 2021

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1beta signaling plays an important role in GAS disease progression.

Published research Rheumatic Heart Disease Infectious Diseases Group A Streptococcal & Rheumatic Heart Disease Invasive Streptococcus A Disease
October 2021

Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study

Acute rheumatic fever is infrequently diagnosed in sub-Saharan African countries despite the high prevalence of rheumatic heart disease. We aimed to determine the incidence of acute rheumatic fever in northern and western Uganda.

Published research Rheumatic Heart Disease Infectious Diseases Group A Streptococcal & Rheumatic Heart Disease Skin Health