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Prof Jonathan Carapetis

October 2020

Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection

Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for development of better long-acting penicillin preparations to prevent RHD.

Published research Immunisation Rheumatic Heart Disease Infectious Diseases Group A Streptococcal & Rheumatic Heart Disease Infectious Diseases Epidemiology
June 2020

Progress towards a coordinated, national paediatric antimicrobial resistance surveillance programme

These data support that children are not just 'little adults' in the AMR era, and analyses by age group are important to detect differences in antibiotic susceptibility

Published research Infectious Diseases Group A Streptococcal & Rheumatic Heart Disease Infectious Diseases Epidemiology Skin Health