Team
Human Immunology projects
Reports and Findings
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels.
Published research Human ImmunologyWhole-cell pertussis vaccine in early infancy for the prevention of allergy in children
Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg.
Published research Early Childhood Development Immunisation Human Immunology Ear Health Infectious Disease Implementation Research Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Allergy Immune systemCord-blood respiratory syncytial virus antibodies and respiratory health in first 5 years of life
To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2 years of life, RSV-NA at 3 years, and respiratory health to age 5 years.
Asthma Published research Human Immunology Respiratory viral infectionsWhole‐cell pertussis vaccine in early infancy for the prevention of allergy in children
Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg.
Published research Whooping Cough Human Immunology Ear Health Infectious Disease Implementation Research Infectious Diseases Epidemiology Vaccine Trials Group