Research subsite
Team
Reports and Findings
PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein
A novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
Children's Cancers Published research Oncogenic Signalling LaboratoryDifferential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
These findings implicate the activation of STAT3 as one pathway that may mediate resistance to IGF-II-targeted therapy in HCC
Published research Oncogenic Signalling LaboratoryChanges in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors
Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin
Published research Oncogenic Signalling LaboratoryActivation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response
The functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target
Children's Cancers Published research Brain Tumour Research Oncogenic Signalling Laboratory