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Team

Kirill Alexandrov, Cell Biology and Molecular Medicine – Institute for Molecular Bioscience, Queensland (ARC-linkage grant-funded)

Pilar Blancafort, Cancer Epigenetics – Harry Perkins Institute of Medical Resarch, Perth

Doug Fairlie, Cell Death & Survival Group – Olivia Newton-John Cancer Research Institute, Melbourne (NHMRC grant-funded)

Sue Fletcher and Steve Wilton, Centre for Comparative Genomics – Murdoch University, Perth

David Frank, Medical Oncology – Dana-Farber Cancer Institute, Boston

Yann Gambin, Single Molecule Science – University NSW, Sydney (ARC-linkage grant-funded)

David Lane, A STAR – Singapore

Arturo Sala, Environment and Health – Brunel University, London

Jason Waithman, Tumour Immunology Unit – Telethon Kids Institute, Perth

Genentech – San Francisco

Phoremost – Cambridge UK

August 2018

A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery

This report thus establishes a discovery platform for identifying novel, functional CPPs to expand the delivery landscape of druggable intracellular targets for biological therapeutics

Published research Drug Discovery Unit
July 2018

β-Lactamase Tools for Establishing Cell Internalization and Cytosolic Delivery of Cell Penetrating Peptides

The β-lactamase assays provide compatible tools for functional characterization of CPP activity and the delivery of biological cargos into cells

Published research Drug Discovery Unit
August 2017

Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target Directed Screens

The poor hit rates associated with conventional random peptide libraries present formidable challenges in genetic screening formats with limited throughput.

Published research Drug Discovery Unit
June 2017

Structure-diverse Phylomer libraries as a rich source of bioactive hits from phenotypic and target directed screens against intracellular proteins

Phylomer libraries are being increasingly used in applications such as phenotypic screening where the numbers of peptides which can be feasibly screened is limited

Published research Drug Discovery Unit