Simon Lee Fellow; Program Head, Immunity and Inflammation
BSc (Hons) PhD Immunology & Genomics
Anthony Bosco was awarded his PhD in 2007 from the University of Western Australia. He received Postdoctoral training at the Arizona Respiratory Center and BIO5 Institute, The University of Arizona.
He leads a unique research program that is underpinned by the concept that genes do not exist nor function in isolation, they work together in networks. His lab employs network graph theory and computational systems biology to work backwards (reverse engineering) from genomic profiles of immune responses to reconstruct the wiring diagram of the underlying gene networks. The long term goal of this work is to unlock the basic mechanisms and principles that govern the functionality of the immune system in healthy and diseased states, unveiling actionable possibilities for therapeutic intervention.
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Projects
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Publications
January 2018
Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics
Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
Published research Children's Lung HealthNovember 2017A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations
To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response to stimulation.
Published research InflammationNovember 2017Airway IRF7hi versus IRF7lo molecular response patterns determine clinical phenotypes in children with acute wheezing
We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children.
Published researchOctober 2017Critical role of plasmacytoid dendritic cells in regulating gene expression and innate immune responses to human rhinovirus-16
Though HRVs are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of IFN synthesis.
Published research InflammationAugust 2017Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers
We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception.
Asthma Published research Inflammation Human ImmunologyJuly 2017CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis
CFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease
Cystic Fibrosis Published research Human Immunology Systems ImmunologyMay 2017Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulator
This study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal
Published research Experimental Immunology Human Immunology Systems ImmunologyApril 2017Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity
There has been a coordinated effort from academic institutions and the PI to identify biomarkers that can predict immune checkpoint blockade response in cancer.
Published research Vaccine Trials GroupNovember 2016Respiratory viral infections and host responses; insights from genomics
Review of the viral sensing pathways and organizing principles that govern the innate immune response to infection
Published research Systems ImmunologyOctober 2016Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability
HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15
Published research Systems Immunology Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental HealthSeptember 2016Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease
Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
Asthma Published research Inflammation Systems Immunology Cardiometabolic Sunhealth Airway Epithelial ResearchFebruary 2016Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects
Mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells
Published research Systems ImmunologyJanuary 2016Distinguishing benign from pathologic TH2 immunity in atopic children
In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor
Asthma Published research Allergy & Infectious Diseases Experimental Immunology Human Immunology Systems ImmunologyJanuary 2016Rhinovirus-induced asthma exacerbations and risk populations
Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function
Asthma Published research Systems ImmunologyJanuary 2016Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection
IRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells
Published research Systems ImmunologyJanuary 2016Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses
Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets
Asthma Published research Human Immunology Systems ImmunologyJune 2015Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes
In this rhinovirus study, we first hypothesized that ex vivo human cells response to virus can serve as a proxy for otherwise controversial in vivo human...
Published research Infectious Diseases Systems ImmunologyMarch 2015The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function
In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.
Published research Vitamin D and Sunlight Inflammation Systems Immunology Cardiometabolic SunhealthJanuary 2015Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations
Cancer immunotherapy has shown impressive results, but most patients do not respond.
Children's Cancers Published research Systems ImmunologyJuly 2014Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks
The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs...
Published research Systems ImmunologyMarch 2014Comment on "Drug discovery: Turning the titanic"
We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.
Published research Systems ImmunologyJanuary 2014Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection
Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens.
Published research Systems ImmunologyFebruary 2013In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
Published research Systems Immunology Respiratory Environmental HealthFebruary 2012T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy
To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy.
Published research Child Allergy & Immunology Human Immunology Systems Immunology ORIGINS Food AllergyFebruary 2012A genomics-based approach to assessment of vaccine safety and immunogenicity in children
This methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...
Published research Immunisation Human Immunology Systems Immunology Vaccine Trials GroupJanuary 2012Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes
AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment.
Published research Human Immunology Systems ImmunologyJanuary 2012Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo.
Asthma Published research Systems ImmunologyJanuary 2012Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo.
Asthma Published research Systems ImmunologyJuly 2011Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance
Concerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption...
Published research Immunisation Human Immunology Systems Immunology Ear Health Vaccine Trials GroupMarch 2010Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study
Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children.
Asthma Published research Human Immunology Systems Immunology -
Education and Qualifications