Cancer Centre
Team
Translational Genomics in Leukaemia projects
Reports and Findings
Down syndrome and leukemia: from basic mechanisms to clinical advances
Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades.
Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia Child disabilityA biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial.
Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia GeneticsTracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response
A vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated circulating T follicular helper (cTfh) cells after vaccination. However, the impact of repeated annual vaccinations on long-term protection and seasonal vaccine efficacy remains unclear.
Published research Immunisation Influenza Infectious Diseases Translational Genomics in Leukaemia